What to Know Before Starting GLP-1 Medications for Weight Loss
GLP-1 medication are changing how obesity is treated—but starting without clear, reliable context can lead to confusion or unrealistic expectations.
In this webinar, OrderlyMeds Expert Advisors break down what actually matters before you begin, including how GLP-1s work, what the research shows, and how to think about long-term success.
The conversation is led by:
- Dr. William Yi, board-certified bariatric surgeon with decades of experience treating obesity and metabolic disease
- Kristin Kirkpatrick, RD, registered dietitian with 20+ years of clinical experience in weight loss, metabolic health, and nutrition psychology
This video is designed to help you decide with confidence—not pressure.
Scroll down after the video to review timestamped insights and key takeaways from the webinar.
Key Learnings & Takeaways
Use the timestamps below to jump to what matters most to you.
What GLP-1 Medications Actually Do (02:30–04:00)
GLP-1s aren’t new or unnatural. They’re modified versions of hormones your body already produces—affecting appetite, digestion, blood sugar, and signals in the brain.
They help you feel full sooner, stay full longer, and reduce the drive to eat—without forcing extreme restriction.
Why it matters: Knowing how they work explains both their benefits and their side effects.
GLP-1s Have Over 30 Years of Safety Data (04:00–06:30)
Originally developed for diabetes in the 1990s, GLP-1 medications are among the most studied metabolic drugs available today. Long-term research supports their safety when appropriately prescribed and monitored.
Why it matters: These medications aren’t experimental—and they weren’t rushed to market.
What Weight Loss Looks Like in Real Numbers (06:30–09:30)
Clinical research shows average total body weight loss of:
- ~17% with semaglutide
- ~22% with tirzepatide
Most weight loss happens in the first 6–12 months, then stabilizes. Many people also experience improvements in cardiometabolic health and reduced compulsive eating behaviors.
Why it matters: GLP-1s are powerful tools—but they’re not instant, unlimited, or magic.
Side Effects: What’s Normal vs. What to Discuss (09:30–13:30)
Common side effects include nausea, constipation, diarrhea, and heartburn—especially early on or after dose increases. These are largely related to slowed digestion.
Rare but serious risks (such as pancreatitis or gallstones) should always be reviewed with your provider, particularly if you have relevant medical history.
Why it matters: Most side effects are temporary and manageable with the right support and education.
Nutrition Is Not Optional on GLP-1s (13:30–18:30)
When appetite drops, every bite counts. Nutrition directly impacts:
- Muscle preservation
- Energy levels
- Side-effect severity
- Long-term success after medication
Protein, fiber, healthy fats, and hydration need to be prioritized—intentionally.
Why it matters: Weight loss without nutrition planning increases fatigue and muscle loss.
Supplements, Hydration, and Gut Health (18:30–22:30)
Some people may benefit from supplements like omega-3s, vitamin D, B12, fiber, or probiotics—but needs vary. Hydration often drops unintentionally and should be monitored closely.
Why it matters: Reduced intake can create nutrient gaps if you don’t plan ahead.
Expert Answers to Common Questions (22:30–30:00)
Dr. Yi and Kristin answer the most common questions they hear from patients and clients, including:
- How to reduce nausea (such as smaller, more frequent meals)
- How much protein you may need while on GLP-1s
- When electrolytes are actually helpful—and when they aren’t
- How to adjust nutrition as appetite changes
Why it matters: Small, informed adjustments can make a big difference in comfort and consistency.
Who Is—and Isn’t—a Good Candidate (30:00–34:30)
Providers consider factors like medical history, insulin resistance, menopause, prior weight-loss attempts, mental health, and disordered eating history before prescribing GLP-1s.
Why it matters: These medications are effective—but they aren’t right for everyone.e a big difference in comfort and consistency.
Emotional and Physical Changes Over Time (34:30–39:30)
Many people experience:
- Reduced “food noise”
- Temporary fatigue or irritability early on
- Greater confidence and mental freedom around food over time
The first 4–6 weeks are often the hardest, followed by improvement.
Why it matters: Early discomfort doesn’t predict long-term results.
What Happens If You Stop Taking GLP-1s (39:30–44:30)
GLP-1s work best as a jumpstart, not a crutch. Whether weight is regained depends largely on the habits and nutrition strategies built while on medication.
Why it matters: The medication supports change—it doesn’t replace it.
Ready to Take the Next Step?
This webinar is just one example of how OrderlyMeds supports you throughout your weight-loss journey. Dr. Yi and Kristin don’t just explain GLP-1 medications—they model the kind of expert, ongoing guidance you receive as part of the OrderlyMeds program.
Beyond your initial evaluation, OrderlyMeds offers continued, expert-led support through educational webinars, a growing library of trusted resources, and access to real providers who understand the full picture—not just the prescription. You’re never left to figure things out on your own.
If you’re considering GLP-1s and want care that’s transparent, personalized, and built for long-term success, OrderlyMeds is here to guide you every step of the way.
Explore OrderlyMeds plans and pricing →
https://orderlymeds.com/pricing/
You don’t have to do this alone. We’re with you—start to steady.
