Starting GLP-1 medications is a powerful step toward your health and weight loss goals. The first month is about helping your body adjust to the medication—especially if you’re starting at the lowest dose.
GLP-1s work differently for everyone—but there are clear trends and common experiences in the first few weeks. Here’s what to expect:
Your Body is Adjusting—Slow and Steady Wins
If you’re starting at the lowest dose, it’s by design. The medication needs time to get used to your body. Increasing the dose too quickly can lead to stronger side effects. Slow titration helps minimize discomfort and optimize long-term results.
Appetite Changes Begin
You may notice a reduced appetite or less “food noise.”
Many people feel full faster and stay full longer, even with smaller meals.
Weight Loss Starts Gradually
Some people lose a few pounds in the first few weeks. Others may not see much change right away.
That’s completely normal. Early results vary—especially on lower doses. Be patient and consistent.
Mild Digestive Side Effects Are Common
Nausea, constipation, bloating, or cramping may occur, especially early on.
These side effects are typically mild and manageable. Try small, frequent meals and stay well-hydrated.
Focus on Protein and Fluids
Since you’re eating less, make every bite count.
Prioritize protein to help prevent fatigue, hair thinning, or muscle loss.
Drink plenty of water to support digestion and ease side effects.
You May Stay on a Low Dose Longer
If side effects are uncomfortable, your provider may keep you at a low dose a bit longer.
That’s okay. Many people see meaningful results without needing to increase right away.
Track Your Progress—Beyond the Scale
Changes in energy, hunger, or how your clothes fit are all signs of progress.
Consider using a fitness tracker or app to stay mindful of your habits.
Support Is Available
You’re not doing this alone.
Use the Patient Portal to message your provider with questions or concerns anytime.
Stick With It—Don’t Quit Too Early
Nearly 1 in 4 people stop taking GLP-1s within the first 3 months.
Most long-term success happens between 6 and 12 months.
Stay committed. This is the time to build sustainable habits that support your goals.
Our team is here to support you through every phase of your GLP-1 journey. With guidance from medical experts and real-life tips from fellow members, we’re committed to helping you feel confident and informed from day one.
All content in this article is sourced from the webinar Starting Strong: Guide to Starting GLP-1 Medications hosted by Dr. William Yi.
