As you start your semaglutide treatment, understanding how to store it properly is important for getting the most out of the medication. Whether you’re using the injectable form or the oral version, each requires different storage methods to remain effective. Knowing the correct way to store your medication will help you avoid costly mistakes and ensure that it works as intended throughout your treatment.
Does Semaglutide Need to Be Refrigerated?
If you’re using semaglutide injections, yes, your semaglutide needs to be refrigerated. Keeping injectable semaglutide cold is vital for maintaining its potency. By storing it in the fridge, you prevent the medication’s active ingredients from breaking down, which can happen if it’s stored at the wrong temperature. However, be sure to never freeze the medication. Freezing can cause it to lose its effectiveness, meaning you won’t get the full benefits of appetite suppression or weight loss.
Does Oral Semaglutide Need to Be Refrigerated?
For oral semaglutide, the storage rules are a bit different. Unlike the injectable form, you can store the oral tablets at room temperature. Just make sure you keep them in a cool, dry place—a kitchen cabinet away from heat sources like your stove or direct sunlight is perfect.
Semaglutide Storage Temperature
Each form of semaglutide has specific temperature requirements to ensure its active ingredients remain stable. Storing it outside these ranges can lead to reduced potency and affect the medication’s ability to deliver the desired results.
Here’s a breakdown of the temperature ranges for different semaglutide products:
| Product | Storage Temperature |
| Compounded Injections | 36°F to 46°F (2°C to 8°C) |
| Compounded Tablets | 59°F to 86°F (15°C to 30°C) |
| Wegovy | 36°F to 46°F (2°C to 8°C) |
Why Does Semaglutide Need to Be Refrigerated
Semaglutide works by mimicking a hormone called GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar levels and control appetite. However, this hormone-like compound is delicate and can lose its efficacy if stored improperly. According to the FDA, medications that are biologically active and contain peptide compounds like semaglutide must be stored at controlled temperatures to prevent protein degradation. Without proper storage, semaglutide won’t work as effectively, meaning you may not see the results you expect from your treatment.
How Long Does Compounded Semaglutide Last In the Fridge?
When stored correctly in the refrigerator, compounded semaglutide injections typically last for about 30 days. Just like when it’s stored improperly, the expiration of semaglutide means that the active ingredients degrade over time, and the medication no longer provides the desired results, such as appetite suppression or craving control.
Expired semaglutide should never be used. Not only does it lose its effectiveness, but taking expired medication can lead to unpredictable results, and in some cases, it could even cause unwanted side effects. For your health and safety, keep track of the expiration date and make sure to dispose of any unused or expired vials. Proper storage within the fridge, combined with careful monitoring of expiration dates, helps ensure your treatment remains as effective as possible.
How Long Can Semaglutide Be Out of the Refrigerator?
If you’re traveling or your semaglutide arrives while you’re not home, you might wonder how long can semaglutide be out of the refrigerator without compromising its effectiveness. In general, semaglutide can safely remain at room temperature for up to 24 hours.
While 24 hours is the maximum amount of time that semaglutide can be safely stored outside the fridge, it’s essential to keep it in a cool, dry place during that period. Avoid placing it near direct sunlight, heat sources, or in humid areas, as this could accelerate the breakdown of the medication. After 24 hours, the risk of diminished effectiveness increases, and it’s safer to discard the medication if it hasn’t been stored at the correct temperature.
If you’re unsure about the state of your medication after it has been out of the fridge for a while, consult with your healthcare provider or pharmacist. They can help you determine whether it’s safe to continue using the medication or if it needs to be replaced.
How to Store Semaglutide at Home
Once your semaglutide medication arrives, the key is to store the vial properly in the refrigerator. Place the vial in the main compartment of your fridge, where the temperature is most consistent. Avoid storing it in the door, as the temperature fluctuates with frequent opening and closing. Ideal spots to store your semaglutide include the back of the fridge or a middle shelf, where the temperature remains stable between 36°F and 46°F (2°C to 8°C).
How to Store Semaglutide When Traveling
Traveling with semaglutide requires some extra care to keep your medication at the right temperature. Whether you’re on a long road trip or flying, here are the best ways to store both injectable and oral semaglutide.
- Use an Insulated Cooler or Travel Case: Pack semaglutide in an insulated cooler bag or case with ice packs to maintain the temperature range of 36°F to 46°F (2°C to 8°C).
- Airline Travel: Keep the medication in your carry-on luggage with ice packs, ensuring it stays cool during the flight.
- Avoid Heat: Never leave semaglutide in direct sunlight or a hot car, as heat can degrade the medication.
- Keep It Cool and Dry: Store oral semaglutide in a cool, dry place, especially when traveling to warm climates. A travel pill box is a good option for protection.
OrderlyMeds Prioritizes Semaglutide Safety
Semaglutide’s effectiveness depends not only on proper at-home storage but also on how it’s transported. OrderlyMeds takes extra precautions to ensure your semaglutide stays at the right temperature during shipping. We use insulated packaging and cooling gel packs to maintain the required temperature range (36°F to 46°F or 2°C to 8°C), reducing the risk of temperature-related issues.
These specialized shipping protocols help ensure your medication remains cool and effective, from the moment it leaves the warehouse to when it arrives at your door, ready to deliver the weight loss and appetite suppression benefits you expect.
Enjoy Peace of Mind with Semaglutide Injections from OrderlyMeds
At OrderlyMeds, we understand that successful weight loss is not just about medication; it’s about holistic care. Our approach goes beyond providing semaglutide medications—we focus on providing comprehensive support through mental health, behavioral strategies, and emotional guidance to ensure long-term success. With our combination of clinical expertise and ongoing personalized care, you can trust that you’re supported every step of the way on your weight loss journey.



