Semaglutide mimics the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body, facilitating the regulation of blood sugar levels by stimulating insulin release, slowing gastric emptying which makes you feel full longer, and reducing appetite.¹

Semaglutide injections are used alongside an individualized low-calorie, low-fat diet and exercise program to assist with weight loss in obese or overweight adults, especially those who may have high blood pressure, diabetes, cardiovascular disease, or high cholesterol. Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It works by enhancing insulin secretion and reducing glucagon levels, which helps lower blood sugar. Additionally, semaglutide slows gastric emptying, which can decrease appetite and contribute to weight loss.²

Compounded semaglutide is given as a subcutaneous injection. Recommended sites include the abdomen (at least 2 inches from the belly button), the front or outer thigh, and the outer back of the upper arm (with assistance).
Key Points to Remember:
- Rotate injection sites with each dose and avoid areas with scar tissue, moles, or bruises. Do not inject through clothing.
- Ensure the liquid in the syringe is clear and colorless. Discard it if cloudy or discolored.
- Use a new needle for each injection.
- Never share syringes, as this can spread infections.
- Administer the medication on the same day each week, at any time, with or without meals.
- Follow the specific instructions provided, and consult your doctor or healthcare professional if you have questions about the technique. Detailed instructions are also included with your medication.³

Compounded semaglutide is legal. Compounders may prepare compounded versions of a drug on FDA’s drug shortages list if the compounded drug meets certain conditions detailed in federal law. Currently, compound semaglutide is listed on the FDA's drug shortage list.⁴

Our Compounded Semaglutide injections are available for as little as $166 per month when purchased as a 3 month starter program ($498 total for 3 months), or $249 per month when purchased month to month. Our starter program includes one vial, with 4 doses each of .25mg, .5mg, and 1mg, and is intended for use by those just getting started on a GLP-1 medication, or for those looking to start on the lowest dose available.
This price covers 100% of the costs, including your online telehealth visit, unlimited check-ins, and shipping. There are no additional fees—membership prices and subscription commitments are not required to purchase injectable compounded semaglutide from OrderlyMeds.

Results can vary significantly among individuals. Clinical studies show that semaglutide typically leads to around 15% weight loss per year. Factors such as starting weight, diet, exercise, medication adherence, and individual metabolism influence outcomes. Weight loss generally occurs gradually, and significant results are not guaranteed for everyone. Combining GLP-1s with healthy eating and regular exercise can enhance results. During your monthly check-in, you will inform our medical team about your progress on your current dose and whether you would like to remain on that dose or increase to the next one to help ensure you are meeting your goals.

Weight loss can vary among patients; some see results right away, while others may take a month or more. Consistency is key. Continue taking the medication as directed, and our medical team will adjust your dose as needed to optimize your weight loss. On average, a safe rate is typically 1-2 pounds per week (or 6-8 pounds per month), but individual targets may vary.

Big Pharma brands Wegovy® and Ozempic® use the active ingredient semaglutide. We compound semaglutide medication to your specific dosing needs and ship it in a glass vial with alcohol prep pads and syringes, resulting in significantly less waste (and cost) compared to the Big Pharma brands, which range from $1,100 to $1,600 when not covered by insurance. Compounded medication is a great option for those seeking an affordable alternative when their insurance does not cover weight loss medications.

Our injectable compounded semaglutide is available in all 50 states.

In clinical trials, both semaglutide injections and oral tablets caused significant weight loss compared to other weight loss drugs and placebo. Semaglutide injections resulted in slightly more weight loss than oral tablets. However, oral tablets can be an attractive option for users who can’t or don’t want to use injections.

Our licensed providers will determine your eligibility for a compounded semaglutide injection prescription. Our general requirements include:
- You must be 18 years old or older
- Have a BMI greater than 27
- Are not pregnant
- Do not have certain medical conditions (i.e. thyroid cancer or hyperthyroidism, gastroparesis, pancreatic cancer or pancreatitis, MEN2 syndrome, or inflammatory bowel disease).
This is not a complete list of qualifying requirements. As a part of our process, you will need to complete an online health screening with our telehealth providers to ultimately determine whether you are eligible to be prescribed compounded semaglutide injections.

When starting semaglutide, you'll begin with a 0.25mg starter dose for the first 4 weeks. This helps your body adjust, so full effects may not be noticeable until your second month. Don’t worry; this is part of the process.
If you’ve previously taken a GLP-1 medication, you can start at your last prescribed dose by providing valid proof of your prescription during the health screening. Please note, if we do not receive the proper documentation, our providers will have to prescribe you at the starting dose.

There are no specific foods to avoid while taking semaglutide, but follow your doctor’s or dietitian’s exercise and dietary recommendations. A healthy diet and regular exercise will help manage your weight and enhance the effectiveness of semaglutide. To minimize side effects and support weight loss, consider these guidelines:
- Avoid fatty, fried, high-sugar, and unhealthy fast foods
- Limit alcohol consumption
- Stay hydrated by drinking plenty of water

Common side effects of compound semaglutide include nausea, abdominal pain, dizziness, bloating, and belching. Not everyone will experience them, and many find that side effects diminish as their body adjusts to the medication. If you have concerns, please contact our healthcare team or your primary care physician.2 For a complete list of potential side effects, visit: [https://orderlymeds.com/safety-information]

Inject the missed dose as soon as you remember it. However, if more than 5 days have passed since your missed dose, skip the missed dose and continue your regular dosing schedule. Do not inject a double dose to make up for a missed one.²

Keep vials, syringes, needles, and medicines out of reach of children. Store away from light and heat. Refrigerate unused semaglutide (36°F to 46°F [2°C to 8°C]), but not near the cooling element. Do not freeze; discard if frozen.
Dispose of unneeded medications safely to prevent accidental ingestion. Do not flush them down the toilet; use a medicine take-back program instead. Contact your pharmacist or local waste department for options, or visit the FDA's Safe Disposal of Medicines website for more information: https://goo.gl/c4Rm4p.2

You can view comprehensive safety information here: https://orderlymeds.com/safety-information

1. Semaglutide | FDA

2. Semaglutide Injections | MedlinePlus

3. Semaglutide Injections | Mayo Clinic

4. FDA Drug Shortages | Semaglutide

5. Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation