Semaglutide mimics the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body, facilitating the regulation of blood sugar levels by stimulating insulin release, slowing gastric emptying which makes you feel full longer, and reducing appetite.¹

Sublingual semaglutide tablets are used alongside an individualized low-calorie, low-fat diet and exercise program to assist with weight loss in obese or overweight adults, especially those who may have high blood pressure, diabetes, cardiovascular disease, or high cholesterol. Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It works by enhancing insulin secretion and reducing glucagon levels, which helps lower blood sugar. Additionally, semaglutide slows gastric emptying, which can decrease appetite and contribute to weight loss.

Compounded oral semaglutide is a once-daily sublingual tablet. To use, place the tablet under the tongue and let it dissolve. Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving. Take this medication once daily, at the same time each day.³

Compounded semaglutide is legal. Compounders may prepare compounded versions of a drug on FDA’s drug shortages list if the compounded drug meets certain conditions detailed in federal law. Currently, compound semaglutide is listed on the FDA's drug shortage list.⁴

Compounded semaglutide tablets come in the form of daily sublingual tablets in dosages of 0.25 mg, 0.5 mg, or 1 mg.

Our sublingual compounded semaglutide tablets are $324/month for 30 daily doses, regardless of dose strength. This covers 100% of the costs, including your online telehealth visit, unlimited check ins, and shipping. There are no other fees - membership prices and subscription commitments are not required to purchase sublingual compounded semaglutide from OrderlyMeds.

Results can vary significantly among individuals. Clinical studies show that semaglutide typically leads to around 15% weight loss per year. Factors such as starting weight, diet, exercise, medication adherence, and individual metabolism influence outcomes. Weight loss generally occurs gradually, and significant results are not guaranteed for everyone. Combining GLP-1s with healthy eating and regular exercise can enhance results. During your monthly check-in, you will inform our medical team about your progress on your current dose and whether you would like to remain on that dose or increase to the next one to help ensure you are meeting your goals.

Weight loss can vary among patients; some see results right away, while others may take a month or more. Consistency is key. Continue taking the medication as directed, and our medical team will adjust your dose as needed to optimize your weight loss. On average, a safe rate is typically 1-2 pounds per week (or 6-8 pounds per month), but individual targets may vary.

Big Pharma brand Rybelsus® uses the active ingredient semaglutide. We compound sublingual semaglutide to meet your specific dosing needs at a significantly lower cost compared to the brand-name option, which ranges from $1,100 to $1,345 when not covered by insurance. Compounded medication is an excellent choice for those seeking an affordable option when their insurance does not cover weight loss medications.

In clinical trials, both semaglutide injections and oral tablets caused significant weight loss compared to other weight loss drugs and placebo. Semaglutide injections resulted in slightly more weight loss than oral tablets. However, oral tablets can be an attractive option for users who can’t or don’t want to use injections.⁵

Our compounded semaglutide tablets are available in all 50 states.

Our licensed providers will determine your eligibility for a compounded semaglutide injection prescription. Our general requirements include:
- You must be 18 years old or older
- Have a BMI greater than 27
- Are not pregnant
- Do not have certain medical conditions (i.e. thyroid cancer or hyperthyroidism, gastroparesis, pancreatic cancer or pancreatitis, MEN2 syndrome, or inflammatory bowel disease).
This is not a complete list of qualifying requirements. As a part of our process, you will need to complete an online health screening with our telehealth providers to ultimately determine whether you are eligible to be prescribed compounded semaglutide injections.

When starting semaglutide, you'll begin with a 0.25mg starter dose for the first 4 weeks. This helps your body adjust, so full effects may not be noticeable until your second month. Don’t worry; this is part of the process.
If you’ve previously taken a GLP-1 medication, you can start at your last prescribed dose by providing valid proof of your prescription during the health screening. Please note, if we do not receive the proper documentation, our providers will have to prescribe you at the starting dose.

There are no specific foods to avoid while taking semaglutide, but follow your doctor’s or dietitian’s exercise and dietary recommendations. A healthy diet and regular exercise will help manage your weight and enhance the effectiveness of semaglutide. To minimize side effects and support weight loss, consider these guidelines:
- Avoid fatty, fried, high-sugar, and unhealthy fast foods
- Limit alcohol consumption
- Stay hydrated by drinking plenty of water

Common side effects of compound semaglutide include nausea, abdominal pain, dizziness, bloating, and belching. Not everyone will experience them, and many find that side effects diminish as their body adjusts to the medication. If you have concerns, please contact our healthcare team or your primary care physician.2 For a complete list of potential side effects, visit: [https://orderlymeds.com/safety-information].

Keep medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Dispose of unneeded medications safely to prevent accidental ingestion. Do not flush them down the toilet; use a medicine take-back program instead. Contact your pharmacist or local waste department for options, or visit the FDA's Safe Disposal of Medicines website for more information: https://goo.gl/c4Rm4p.2

You can view comprehensive safety information here: https://orderlymeds.com/safety-information

1. Semaglutide | FDA

2. Oral Semaglutide| MedlinePlus

3. Oral Semaglutide | Mayo Clinic

4. FDA Drug Shortages | Semaglutide

5. Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation